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Index > Protein center > ITGAV(Gene name) > Bovine
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  • ITGAV (Gene name),
  • Integrin alpha-V (Protein name ),  ITAV_BOVIN from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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  • 3D
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  • Predicted Eptitope
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  • Vaild Sequence
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  • Gene name:
    ITGAV;
    Protein name:
    Integrin alpha-V;
    Alternative:
    Vitronectin receptor subunit alpha;
    CD:
    CD51;
    Organism:
    Bovine (Bos taurus). 
    General Annotation
    Sub Unit:
    Interacts with RAB25 (By similarity). Heterodimer of an alpha and a beta subunit. The alpha subunit is composed of an heavy and a light chain linked by a disulfide bond. Alpha-V associates with either beta-1, beta-3, beta-5, beta-6 or beta-8. Alpha-V/beta-6 and alpha-V/beta-3 bind to foot-and-mouth disease virus (FMDV) VP1 protein and acts as a receptor for this virus.
    Function:
    The alpha-V integrins are receptors for vitronectin, MFGE8, cytotactin, fibronectin, fibrinogen, laminin, matrix metalloproteinase-2, osteopontin, osteomodulin, prothrombin, thrombospondin and vWF. They recognize the sequence R-G-D in a wide array of ligands.
    Subcellular Location:
    Membrane Single-pass type I membrane protein
    Protein Attributes:
    Sequence length:
    1048
    Sequence:
    50:
    MAFPPRRRLR | LGPRGLPLLL | SGLLLPLCRA | FNLDVESPAE | YSGPEGSYFG | 
    100:
    FAVDFFVPSA | SSRMFLLVGA | PKANTTQPGI | VEGGQVLKCD | WSSHRRCQPI | 
    150:
    EFDATGNRDY | AKDDPLEFKS | HQWFGASVRS | KQDKILACAP | LYHWRTEMKQ | 
    200:
    EREPVGTCFL | QDGTKTVEYA | PCRSKNIDAD | GQGFCQGGFS | IDFTKADRVL | 
    250:
    LGGPGSFYWQ | GQLISDQVAE | IVSKYDPKVY | SIKYNNQLAT | RTAQAIFDDS | 
    300:
    YLGYSVAVGD | FNGDGIDDFV | SGVPRAARTL | GMVYIYDGKN | MSSLHNFTGE | 
    350:
    QMAAYFGFSV | AATDINGDDY | ADVFIGAPLF | MDRGSDGKLQ | EVGQVSVSLQ | 
    400:
    KASGDFQTIK | LNGFEVFARF | GSAIAPLGDL | DQDGFNDIAI | AAPYGGEDKK | 
    450:
    GIVYIFNGRP | TGLNAVPSQI | LEGKWAARSM | PPSFGYSMKG | ATDIDKNGYP | 
    500:
    DLIVGAFGVD | RAVLYRARPV | ITVNAGLEVY | PSILNQENKT | CPLPGTDLKV | 
    550:
    SCFNVRFCLK | ADGKGALPTK | LDFQVELLLD | KLKQKGAIRR | ALFLHNRSPG | 
    600:
    HSKNMTISRG | GQMQCEELIA | YLRDESEFRD | KLTPITIFME | YWLDYRTAAD | 
    650:
    ATGLQPILNQ | FTPANVSRQA | HILLDCGEDN | VCKPKLEVSV | DSDQKKIYIG | 
    700:
    DDNPLTLIVK | AQNQGEGAYE | AELIVSIPLQ | ADFIGVVRNS | EALARLSCAF | 
    750:
    KTENQTRQVV | CDLGNPMKAG | TQLLAGLRFS | VHQQSEMDTS | VKFDLQIQSS | 
    800:
    NLFDKVSPVV | SYKVDLAVLA | AVEIRGVSSP | DHIFLPIPNW | KYKENPETEE | 
    850:
    DVGPVVQHIY | ELRNNGPSSF | SKAMLHLQWP | YKYNNNTLLY | ILQYDIDGPM | 
    900:
    NCTSDMEINP | LRIKISNSQT | SEKNDTVGGQ | GDRNHLITKR | DLTLNEGDVH | 
    950:
    TLGCGIAECL | KIVCQVGRLD | RGKSAILYVR | SLLWTETFMN | KENQNHSYSL | 
    1000:
    KSSASFNVIE | FPYKNLPIED | IFNSTLVTTN | VTWGIQPAPM | PVPVWVIILA | 
    1048:
    VLAGLLLLAV | LVFVMYRMGF | FKRVRPPQEE | QEREQLQPHE | NGEGNSET
    3D Structure:
    N/A
    Predicted Eptitope:
    Please Sign in.
    EIAab Sequence  Vaild Sequence:
    Please Sign in.
    Related Databases
    String:
    UniGene:
    SMR:
    Pfam:
    Uniprot:
     
    FOR
    ELISA Kit for Bovine Integrin alpha-V
    Cat.:
    E0271h
    Price:
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    MSDS:
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    Packing:
    96T
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    ELISA Kit for Bovine Integrin alpha-V
    Cat.:
    E0271b
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    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Range:
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    ELISA Kit for Bovine Integrin alpha-V
    Cat.:
    E0271m
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    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Range:
    Please sign in first.
    ELISA Kit for Bovine Integrin alpha-V
    Cat.:
    E0271c
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    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Range:
    Please sign in first.
    CLIA Kit for Bovine Integrin alpha-V
    Cat.:
    U0271c
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Bovine Integrin alpha-V
    Cat.:
    U0271b
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Bovine Integrin alpha-V
    Cat.:
    U0271h
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Bovine Integrin alpha-V
    Cat.:
    U0271m
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Polyclonal Antibody for Bovine Integrin alpha-V
    Polyclonal Antibody for Bovine Integrin alpha-V
    Cat.:
    P0271Rb-m
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Bovine Integrin alpha-V
    Polyclonal Antibody for Bovine Integrin alpha-V
    Cat.:
    P0271Rb-h
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Monoclonal Antibody for Bovine Integrin alpha-V
    Monoclonal Antibody for Bovine Integrin alpha-V
    Monoclonal Antibody for Bovine Integrin alpha-V
    Monoclonal Antibody for Bovine Integrin alpha-V
    Protein for Bovine Integrin alpha-V
    Protein for Bovine Integrin alpha-V
    Protein for Bovine Integrin alpha-V
    Protein for Bovine Integrin alpha-V

    R&D Technical Data
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    Precision
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    Recovery
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    Linearity
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    References
    1. 1.
      "High-efficiency utilization of the bovine integrin alpha(v)beta(3) as a receptor for foot-and-mouth disease virus is dependent on the bovine beta(3) subunit."
      Neff S. , Mason P.W. , Baxt B.
      J. Virol.74:7298-7306(2000) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA];INTERACTION WITH FMDV CAPSID PROTEINS
      tissue: Lung.
    2. 2.
      "Molecular cloning and characteristics of bovine alpha V cDNA."
      Du J. , Chang H. , Cong G. , Shao J. , Lin T. , Liu Z. , Liu X. , Cai X. , Xie Q.
      Submitted (2006-07) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA]
      tissue: Lung.
    3. 3.
      "Bovine alpha-V integrin subunit (fragment)."
      Andersen M.H. , Rasmussen J.T. , Berglund L. , Petersen T.E.
      Submitted (2000-10) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 42-1048
      tissue: Mammary gland.
    4. 4.
      "Bovine PAS-6/7 binds alpha v beta 5 integrins and anionic phospholipids through two domains."
      Andersen M.H. , Berglund L. , Rasmussen J.T. , Petersen T.E.
      Biochemistry36:5441-5446(1997) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PROTEIN SEQUENCE OF 31-50 AND 891-910
      tissue: Mammary gland.
    5. 5.
      "Foot-and-mouth disease virus receptors: comparison of bovine alpha(V) integrin utilization by type A and O viruses."
      Duque H. , Baxt B.
      J. Virol.77:2500-2511(2003) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH HOST FMDV VP1
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